CCR7 (CCR7)

CCR7
CCR7
Идентификаторы
Символ	CCR7 ; BLR2; CD197; CDw197; CMKBR7; EBI1
Внешние ID	OMIM: 600242 MGI: 103011 HomoloGene: 1387 IUPHAR: CCR7 ChEMBL: 4594 GeneCards: Ген CCR7
Функция	• G-protein coupled receptor activity; • C-C chemokine receptor activity; • chemokine (C-C motif) ligand 19 binding; • chemokine (C-C motif) ligand 21 binding; • C-C motif chemokine 19 receptor activity; • C-C motif chemokine 21 receptor activity;
Компонент клетки	• intracellular; • plasma membrane; • external side of plasma membrane; • integral component of membrane;
Биологический процесс	• establishment of T cell polarity; • positive regulation of cell-matrix adhesion; • dendritic cell chemotaxis; • myeloid dendritic cell chemotaxis; • positive regulation of dendritic cell antigen processing and presentation; • positive regulation of hypersensitivity; • positive regulation of humoral immune response; • inflammatory response; • immune response; • G-protein coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • positive regulation of actin filament polymerization; • positive regulation of pseudopodium assembly; • ruffle organization; • response to lipopolysaccharide; • regulation of interferon-gamma production; • positive regulation of interleukin-12 production; • activation of Rho GTPase activity; • response to prostaglandin E; • chemokine (C-C motif) ligand 19 signaling pathway; • chemokine (C-C motif) ligand 21 signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of phosphatidylinositol 3-kinase activity; • negative thymic T cell selection; • positive regulation of cell adhesion; • positive regulation of protein kinase activity; • positive regulation of JNK cascade; • regulation of interleukin-1 beta secretion; • positive regulation of T cell receptor signaling pathway; • release of sequestered calcium ion into cytosol; • positive regulation of filopodium assembly; • positive regulation of protein kinase B signaling; • chemokine-mediated signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • cellular response to cytokine stimulus; • response to nitric oxide; • interleukin-12 secretion; • positive regulation of neutrophil chemotaxis; • lymphocyte migration into lymph node; • mature dendritic cell differentiation; • negative regulation of leukocyte apoptotic process; • positive regulation of cell motility; • positive regulation of dendritic cell chemotaxis; • positive regulation of immunological synapse formation; • positive regulation of T cell costimulation; • positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation; • regulation of dendritic cell dendrite assembly;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
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Ортологи

CCR7 (C-C-рецептор хемокина 7, англ. C-C chemokine receptor type 7) — рецептор β-хемокинов млекопитающих класса интегральных мембранных белков. CCR7 является рецептором для двух лигандов: хемокинов CCL19 и CCL21.^[1] Продукт гена CCR7.

Функции

Белок CCR7 входит в семейство рецепторов, сопряжённых с G-белком. Он был первоначально идентифицирован как ген, индуцируемый вирусом Эпштейна — Барр и считался медиатором эффекта вируса на B-лимфоциты. CCR7 экспрессирован на клетках различных лимфоидных тканей и активирует B- и T-лимфоциты. Рецептор контролирует миграцию Т-клеток памяти во вторичные лимфоидные органы, такие как лимфатические узлы, а также стимулирует созревание дендритных клеток.

Клиническое значение

CCR7 представлен на различных раковых клетках, таких как немелкоклеточный рак лёгкого, рак желудка и рак пищевода.^[2]^[3]^[4] Экспрессия CCR7 на раковых клетках связана с их метастазировением в лимфатические узлы.^[5]

Примечания

↑ F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
↑ Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)
↑ Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)
↑ Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)
↑ Shields J.D., Fleury M.E., Yong C., Tomei A.A., Randolph G.J., Swartz M.A. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling (англ.) // Cancer Cell : journal. — 2007. — June (vol. 11, no. 6). — P. 526—538. — doi:10.1016/j.ccr.2007.04.020. — PMID 17560334.

Библиография

Müller G., Lipp M. Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking. (англ.) // Microcirculation (New York, N.Y. : 1994) : journal. — 2003. — Vol. 10, no. 3—4. — P. 325—334. — doi:10.1038/sj.mn.7800197. — PMID 12851649.
Burgstahler R., Kempkes B., Steube K., Lipp M. Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2 (англ.) // Biochemical and Biophysical Research Communications^[англ.] : journal. — 1995. — Vol. 215, no. 2. — P. 737—743. — doi:10.1006/bbrc.1995.2525. — PMID 7488016.
Schweickart V.L., Raport C.J., Godiska R., et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2 (англ.) // Genomics : journal. — Academic Press, 1995. — Vol. 23, no. 3. — P. 643—650. — doi:10.1006/geno.1994.1553. — PMID 7851893.

Ссылки

База данных IUPHAR Database of Receptors and Ion Channels. Международный союз фундаментальной и клинической фармакологии.

[1] F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004

[2] Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)

[3] Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)

[4] Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)

[pmid17560334-5] Shields J.D., Fleury M.E., Yong C., Tomei A.A., Randolph G.J., Swartz M.A. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling (англ.) // Cancer Cell : journal. — 2007. — June (vol. 11, no. 6). — P. 526—538. — doi:10.1016/j.ccr.2007.04.020. — PMID 17560334.

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Белки: Кластеры дифференцировки
1-50	CD1 (a-c, 1A, 1D, 1E) CD2 CD3 (γ, δ, ε) CD4 CD5 CD6 CD7 CD8 (a) CD9 CD10 CD11 (a, b, c, d) CD13 CD14 CD15 CD16 (A, B) CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 (A, B) CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 (a, b, c, d) CD43 CD44 CD45 CD46 CD47 CD48 CD49 (a, b, c, d, e, f) CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 (E, L, P) CD63 CD64 (A, B, C) CD66 (a, b, c, d, e, f) CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 (a, b) CD80 CD81 CD82 CD83 CD84 CD85 (a, d, e, h, j, k) CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 (a, b) CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 (a, b) CD121 (a, b) CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 (a, b, c) CD157 CD158 (a, d, e, i, k) CD159 (a, c) CD160 CD161 CD162 CD163 CD164 CD166 CD167 (a, b) CD168 CD169 CD170 CD171 CD172 (a, b, g) CD174 CD177 CD178 CD179 (a, b) CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 (a, b) CD212 CD213a (1, 2) CD217 CD218 (a, b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 (a, b) CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD270 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD319 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351-400	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371