MAD2L1 (MAD2L1)

Митотический блокатор MAD2 дефицитообразный 1 (дрожжи)
Митотический блокатор MAD2 дефицитообразный 1 (дрожжи)
	PDB представлено на основе 1duj.
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 1DUJ, 1GO4, 1KLQ, 1S2H, 2QYF, 2V64, 2VFX, 3GMH
Идентификаторы
Символ	MAD2L1 ; HSMAD2; MAD2
Внешние ID	OMIM: 601467 MGI: 1860374 HomoloGene: 1768 GeneCards: Ген MAD2L1
Функция	• protein binding; • identical protein binding; • protein homodimerization activity;
Компонент клетки	• kinetochore; • condensed chromosome kinetochore; • spindle pole; • nucleus; • nuclear pore; • cytosol; • perinuclear region of cytoplasm; • mitotic spindle;
Биологический процесс	• mitotic sister chromatid segregation; • mitotic cell cycle; • mitotic cell cycle checkpoint; • mitotic spindle assembly checkpoint; • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of protein catabolic process; • negative regulation of apoptotic process; • negative regulation of mitotic cell cycle; • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • negative regulation of mitotic anaphase-promoting complex activity; • positive regulation of mitotic cell cycle spindle assembly checkpoint;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

Белок митотической контрольной точки сборки веретена деления MAD2A (англ. Mitotic spindle assembly checkpoint protein MAD2A) — белок, кодируемый у человека геном MAD2L1 .^[1]^[2]^[3]

Функция

MAD2L1 является компонентом митотической контрольной точки сборки веретена деления, который предотвращает возникновение анафазы до тех пор, пока все хромосомы не будут правильно выровнены на метафазной пластине. MAD2L1 связан с геном MAD2L2, расположенном на хромосоме 1. Псевдоген MAD2 был размещён на хромосоме 14.^[3]

Взаимодействия

MAD2L1, как было выявлено, взаимодействует с:

ADAM17,^[4]^[5]
BUB1B,^[6]
CDC20,^[7]^[8]^[9]^[10]^[11]^[12]^[13]^[14]^[15]^[16]^[17]^[18]
CDC27^[13]^[14] и
NR3A2,^[19]
MAD2L2,^[20]
MAD1,^[20]^[10]^[21] и
UBD.^[22]

Примечания

↑ Li Y., Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2 (англ.) // Science : journal. — 1996. — October (vol. 274, no. 5285). — P. 246—248. — doi:10.1126/science.274.5285.246. — PMID 8824189.
↑ Xu L., Deng H.X., Yang Y., Xia J.H., Hung W.Y., Siddque T. Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization (англ.) // Cytogenet. Cell Genet.^[англ.] : journal. — 1997. — November (vol. 78, no. 1). — P. 63—4. — doi:10.1159/000134631. — PMID 9345911.
↑ ¹ ² Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) (неопр.).
↑ Nelson K.K., Schlöndorff J., Blobel C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta (англ.) // Biochem. J.^[англ.] : journal. — 1999. — November (vol. 343, no. 3). — P. 673—680. — doi:10.1042/0264-6021:3430673. — PMID 10527948. — PMC 1220601.
↑ Poghosyan Z., Robbins S.M., Houslay M.D., Webster A., Murphy G., Edwards D.R. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases (англ.) // J. Biol. Chem. : journal. — 2002. — February (vol. 277, no. 7). — P. 4999—5007. — doi:10.1074/jbc.M107430200. — PMID 11741929.
↑ Sudakin V., Chan G.K., Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 (англ.) // J. Cell Biol.^[англ.] : journal. — 2001. — September (vol. 154, no. 5). — P. 925—936. — doi:10.1083/jcb.200102093. — PMID 11535616. — PMC 2196190.
↑ Zhang Y., Lees E. Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation (англ.) // Mol. Cell. Biol. : journal. — 2001. — August (vol. 21, no. 15). — P. 5190—5199. — doi:10.1128/MCB.21.15.5190-5199.2001. — PMID 11438673. — PMC 87243.
↑ Sihn C.R., Suh E.J., Lee K.H., Kim T.Y., Kim S.H. p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells (англ.) // Cancer Lett.^[англ.] : journal. — 2003. — November (vol. 201, no. 2). — P. 203—210. — doi:10.1016/s0304-3835(03)00465-8. — PMID 14607335.
↑ Luo X., Fang G., Coldiron M., Lin Y., Yu H., Kirschner M.W., Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 (англ.) // Nat. Struct. Biol. : journal. — 2000. — March (vol. 7, no. 3). — P. 224—229. — doi:10.1038/73338. — PMID 10700282.
↑ ¹ ² Sironi L., Melixetian M., Faretta M., Prosperini E., Helin K., Musacchio A. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint (англ.) // EMBO J. : journal. — 2001. — November (vol. 20, no. 22). — P. 6371—6382. — doi:10.1093/emboj/20.22.6371. — PMID 11707408. — PMC 125308.
↑ D'Angiolella V., Mari C., Nocera D., Rametti L., Grieco D. The spindle checkpoint requires cyclin-dependent kinase activity (англ.) // Genes Dev. : journal. — 2003. — October (vol. 17, no. 20). — P. 2520—2525. — doi:10.1101/gad.267603. — PMID 14561775. — PMC 218146.
↑ Kallio M.J., Beardmore V.A., Weinstein J., Gorbsky G.J. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells (англ.) // J. Cell Biol.^[англ.] : journal. — 2002. — September (vol. 158, no. 5). — P. 841—847. — doi:10.1083/jcb.200201135. — PMID 12196507. — PMC 2173153.
↑ ¹ ² Wassmann K., Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1998. — September (vol. 95, no. 19). — P. 11193—11198. — doi:10.1073/pnas.95.19.11193. — PMID 9736712. — PMC 21618.
↑ ¹ ² Kallio M., Weinstein J., Daum J.R., Burke D.J., Gorbsky G.J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events (англ.) // J. Cell Biol.^[англ.] : journal. — 1998. — June (vol. 141, no. 6). — P. 1393—1406. — doi:10.1083/jcb.141.6.1393. — PMID 9628895. — PMC 2132789.
↑ Fang G., Yu H., Kirschner M.W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation (англ.) // Genes Dev. : journal. — 1998. — June (vol. 12, no. 12). — P. 1871—1883. — doi:10.1101/gad.12.12.1871. — PMID 9637688. — PMC 316912.
↑ Skoufias D.A., Andreassen P.R., Lacroix F.B., Wilson L., Margolis R.L. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2001. — April (vol. 98, no. 8). — P. 4492—4497. — doi:10.1073/pnas.081076898. — PMID 11274370. — PMC 31862.
↑ Nilsson J., Yekezare M., Minshull J., Pines J. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction (англ.) // Nat. Cell Biol. : journal. — 2008. — December (vol. 10, no. 12). — P. 1411—1420. — doi:10.1038/ncb1799. — PMID 18997788. — PMC 2635557.
↑ Privette L.M., Weier J.F., Nguyen H.N., Yu X., Petty E.M. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint (англ.) // Neoplasia : journal. — 2008. — July (vol. 10, no. 7). — P. 643—652. — PMID 18592005. — PMC 2435002.
↑ Poelzl G., Kasai Y., Mochizuki N., Shaul P.W., Brown M., Mendelsohn M.E. Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — March (vol. 97, no. 6). — P. 2836—2839. — doi:10.1073/pnas.050580997. — PMID 10706629. — PMC 16016.
↑ ¹ ² Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 (англ.) // J. Biol. Chem. : journal. — 2000. — February (vol. 275, no. 6). — P. 4391—4397. — doi:10.1074/jbc.275.6.4391. — PMID 10660610.
↑ Rual J.F., Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., Berriz G.F., Gibbons F.D., Dreze M., Ayivi-Guedehoussou N., Klitgord N., Simon C., Boxem M., Milstein S., Rosenberg J., Goldberg D.S., Zhang L.V., Wong S.L., Franklin G., Li S., Albala J.S., Lim J., Fraughton C., Llamosas E., Cevik S., Bex C., Lamesch P., Sikorski R.S., Vandenhaute J., Zoghbi H.Y., Smolyar A., Bosak S., Sequerra R., Doucette-Stamm L., Cusick M.E., Hill D.E., Roth F.P., Vidal M. Towards a proteome-scale map of the human protein-protein interaction network (англ.) // Nature : journal. — 2005. — October (vol. 437, no. 7062). — P. 1173—1178. — doi:10.1038/nature04209. — PMID 16189514.
↑ Liu Y.C., Pan J., Zhang C., Fan W., Collinge M., Bender J.R., Weissman S.M. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1999. — April (vol. 96, no. 8). — P. 4313—4318. — doi:10.1073/pnas.96.8.4313. — PMID 10200259. — PMC 16329.

Литература

Maruyama K., Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides (англ.) // Gene^[англ.] : journal. — Elsevier, 1994. — Vol. 138, no. 1—2. — P. 171—174. — doi:10.1016/0378-1119(94)90802-8. — PMID 8125298.
O'Neill T.J., Zhu Y., Gustafson T.A. Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation (англ.) // J. Biol. Chem. : journal. — 1997. — Vol. 272, no. 15. — P. 10035—10040. — doi:10.1074/jbc.272.15.10035. — PMID 9092546.
Suzuki Y., Yoshitomo-Nakagawa K., Maruyama K., Suyama A., Sugano S. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library (англ.) // Gene^[англ.] : journal. — Elsevier, 1997. — Vol. 200, no. 1—2. — P. 149—156. — doi:10.1016/S0378-1119(97)00411-3. — PMID 9373149.
Jin D.Y., Spencer F., Jeang K.T. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 (англ.) // Cell : journal. — Cell Press, 1998. — Vol. 93, no. 1. — P. 81—91. — doi:10.1016/S0092-8674(00)81148-4. — PMID 9546394.
Krishnan R., Goodman B., Jin D.Y., Jeang K.T., Collins C., Stetten G., Spencer F. Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27 (англ.) // Genomics : journal. — Academic Press, 1998. — Vol. 49, no. 3. — P. 475—478. — doi:10.1006/geno.1998.5233. — PMID 9615237.
Kallio M., Weinstein J., Daum J.R., Burke D.J., Gorbsky G.J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events (англ.) // J. Cell Biol.^[англ.] : journal. — 1998. — Vol. 141, no. 6. — P. 1393—1406. — doi:10.1083/jcb.141.6.1393. — PMID 9628895. — PMC 2132789.
Fang G., Yu H., Kirschner M.W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation (англ.) // Genes Dev. : journal. — 1998. — Vol. 12, no. 12. — P. 1871—1883. — doi:10.1101/gad.12.12.1871. — PMID 9637688. — PMC 316912.
Wassmann K., Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1998. — Vol. 95, no. 19. — P. 11193—11198. — doi:10.1073/pnas.95.19.11193. — PMID 9736712. — PMC 21618.
Liu Y.C., Pan J., Zhang C., Fan W., Collinge M., Bender J.R., Weissman S.M. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1999. — Vol. 96, no. 8. — P. 4313—4318. — doi:10.1073/pnas.96.8.4313. — PMID 10200259. — PMC 16329.
Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes (англ.) // Genomics : journal. — Academic Press, 1999. — Vol. 58, no. 2. — P. 181—187. — doi:10.1006/geno.1999.5831. — PMID 10366450.
Nelson K.K., Schlöndorff J., Blobel C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta (англ.) // Biochem. J.^[англ.] : journal. — 1999. — Vol. 343, no. 3. — P. 673—680. — doi:10.1042/0264-6021:3430673. — PMID 10527948. — PMC 1220601.
Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 (англ.) // J. Biol. Chem. : journal. — 2000. — Vol. 275, no. 6. — P. 4391—4397. — doi:10.1074/jbc.275.6.4391. — PMID 10660610.
Luo X., Fang G., Coldiron M., Lin Y., Yu H., Kirschner M.W., Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 (англ.) // Nat. Struct. Biol. : journal. — 2000. — Vol. 7, no. 3. — P. 224—229. — doi:10.1038/73338. — PMID 10700282.
Poelzl G., Kasai Y., Mochizuki N., Shaul P.W., Brown M., Mendelsohn M.E. Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — Vol. 97, no. 6. — P. 2836—2839. — doi:10.1073/pnas.050580997. — PMID 10706629. — PMC 16016.
Steuerwald N., Cohen J., Herrera R.J., Sandalinas M., Brenner C.A. Association between spindle assembly checkpoint expression and maternal age in human oocytes (англ.) // Mol. Hum. Reprod.^[англ.] : journal. — 2001. — Vol. 7, no. 1. — P. 49—55. — doi:10.1093/molehr/7.1.49. — PMID 11134360.
Campbell M.S., Chan G.K., Yen T.J. Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase (англ.) // Journal of Cell Science^[англ.] : journal. — The Company of Biologists^[англ.], 2001. — Vol. 114, no. Pt 5. — P. 953—963. — PMID 11181178.
Zhang Y., Lees E. Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation (англ.) // Mol. Cell. Biol. : journal. — 2001. — Vol. 21, no. 15. — P. 5190—5199. — doi:10.1128/MCB.21.15.5190-5199.2001. — PMID 11438673. — PMC 87243.
Sudakin V., Chan G.K., Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 (англ.) // J. Cell Biol.^[англ.] : journal. — 2001. — Vol. 154, no. 5. — P. 925—936. — doi:10.1083/jcb.200102093. — PMID 11535616. — PMC 2196190.

[pmid8824189-1] Li Y., Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2 (англ.) // Science : journal. — 1996. — October (vol. 274, no. 5285). — P. 246—248. — doi:10.1126/science.274.5285.246. — PMID 8824189.

[pmid9345911-2] Xu L., Deng H.X., Yang Y., Xia J.H., Hung W.Y., Siddque T. Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization (англ.) // Cytogenet. Cell Genet.^[англ.] : journal. — 1997. — November (vol. 78, no. 1). — P. 63—4. — doi:10.1159/000134631. — PMID 9345911.

[entrez-3] ¹ ² Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) (неопр.).

[pmid10527948-4] Nelson K.K., Schlöndorff J., Blobel C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta (англ.) // Biochem. J.^[англ.] : journal. — 1999. — November (vol. 343, no. 3). — P. 673—680. — doi:10.1042/0264-6021:3430673. — PMID 10527948. — PMC 1220601.

[pmid11741929-5] Poghosyan Z., Robbins S.M., Houslay M.D., Webster A., Murphy G., Edwards D.R. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases (англ.) // J. Biol. Chem. : journal. — 2002. — February (vol. 277, no. 7). — P. 4999—5007. — doi:10.1074/jbc.M107430200. — PMID 11741929.

[pmid11535616-6] Sudakin V., Chan G.K., Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 (англ.) // J. Cell Biol.^[англ.] : journal. — 2001. — September (vol. 154, no. 5). — P. 925—936. — doi:10.1083/jcb.200102093. — PMID 11535616. — PMC 2196190.

[pmid11438673-7] Zhang Y., Lees E. Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation (англ.) // Mol. Cell. Biol. : journal. — 2001. — August (vol. 21, no. 15). — P. 5190—5199. — doi:10.1128/MCB.21.15.5190-5199.2001. — PMID 11438673. — PMC 87243.

[pmid14607335-8] Sihn C.R., Suh E.J., Lee K.H., Kim T.Y., Kim S.H. p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells (англ.) // Cancer Lett.^[англ.] : journal. — 2003. — November (vol. 201, no. 2). — P. 203—210. — doi:10.1016/s0304-3835(03)00465-8. — PMID 14607335.

[pmid10700282-9] Luo X., Fang G., Coldiron M., Lin Y., Yu H., Kirschner M.W., Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 (англ.) // Nat. Struct. Biol. : journal. — 2000. — March (vol. 7, no. 3). — P. 224—229. — doi:10.1038/73338. — PMID 10700282.

[pmid11707408-10] ¹ ² Sironi L., Melixetian M., Faretta M., Prosperini E., Helin K., Musacchio A. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint (англ.) // EMBO J. : journal. — 2001. — November (vol. 20, no. 22). — P. 6371—6382. — doi:10.1093/emboj/20.22.6371. — PMID 11707408. — PMC 125308.

[pmid14561775-11] D'Angiolella V., Mari C., Nocera D., Rametti L., Grieco D. The spindle checkpoint requires cyclin-dependent kinase activity (англ.) // Genes Dev. : journal. — 2003. — October (vol. 17, no. 20). — P. 2520—2525. — doi:10.1101/gad.267603. — PMID 14561775. — PMC 218146.

[pmid12196507-12] Kallio M.J., Beardmore V.A., Weinstein J., Gorbsky G.J. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells (англ.) // J. Cell Biol.^[англ.] : journal. — 2002. — September (vol. 158, no. 5). — P. 841—847. — doi:10.1083/jcb.200201135. — PMID 12196507. — PMC 2173153.

[pmid9736712-13] ¹ ² Wassmann K., Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1998. — September (vol. 95, no. 19). — P. 11193—11198. — doi:10.1073/pnas.95.19.11193. — PMID 9736712. — PMC 21618.

[pmid9628895-14] ¹ ² Kallio M., Weinstein J., Daum J.R., Burke D.J., Gorbsky G.J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events (англ.) // J. Cell Biol.^[англ.] : journal. — 1998. — June (vol. 141, no. 6). — P. 1393—1406. — doi:10.1083/jcb.141.6.1393. — PMID 9628895. — PMC 2132789.

[pmid9637688-15] Fang G., Yu H., Kirschner M.W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation (англ.) // Genes Dev. : journal. — 1998. — June (vol. 12, no. 12). — P. 1871—1883. — doi:10.1101/gad.12.12.1871. — PMID 9637688. — PMC 316912.

[pmid11274370-16] Skoufias D.A., Andreassen P.R., Lacroix F.B., Wilson L., Margolis R.L. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2001. — April (vol. 98, no. 8). — P. 4492—4497. — doi:10.1073/pnas.081076898. — PMID 11274370. — PMC 31862.

[pmid18997788-17] Nilsson J., Yekezare M., Minshull J., Pines J. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction (англ.) // Nat. Cell Biol. : journal. — 2008. — December (vol. 10, no. 12). — P. 1411—1420. — doi:10.1038/ncb1799. — PMID 18997788. — PMC 2635557.

[pmid18592005-18] Privette L.M., Weier J.F., Nguyen H.N., Yu X., Petty E.M. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint (англ.) // Neoplasia : journal. — 2008. — July (vol. 10, no. 7). — P. 643—652. — PMID 18592005. — PMC 2435002.

[pmid10706629-19] Poelzl G., Kasai Y., Mochizuki N., Shaul P.W., Brown M., Mendelsohn M.E. Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — March (vol. 97, no. 6). — P. 2836—2839. — doi:10.1073/pnas.050580997. — PMID 10706629. — PMC 16016.

[pmid10660610-20] ¹ ² Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 (англ.) // J. Biol. Chem. : journal. — 2000. — February (vol. 275, no. 6). — P. 4391—4397. — doi:10.1074/jbc.275.6.4391. — PMID 10660610.

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